Life Extension SAMe S-adenosyl-methionine 400 mg 60 enteric coated table

SAMe helps maintain stable mood and joint function without side effects. In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. Largely known for its effects on optimal mood, SAMe has also shown benefits for the liver, brain, and joints.

Benefits at a glance:

• Helps maintain stable mood
• Helps maintain liver health
• Helps maintain healthy joint function

Life Extension® first introduced SAMe (S-Adenosyl-Methionine) in 1997, and researchers continue to discover impressive benefits of this versatile nutrient.

SAMe is an amino acid derivative normally synthesized in the body that may become depleted with sickness or age. Supplementing with SAMe plus folate, trimethylglycine (TMG or betaine), vitamins B6 and B12 appears to be an effective way to overcome this deficiency.

SAMe is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, and catecholamines and other neurotransmitters. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin. which are necessary for cognitive function.

SAMe is used by the body in three important pathways:

• Methylation (contributing methyl groups to activate certain molecules)
• The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)
• Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)

In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Its findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects.

SAMe has multimodal mechanisms of action that are used throughout the body and especially in the liver.

A recent study conducted at Harvard Medical School and Massachusetts General Hospital cited the benefits of SAMe for mood elevation. In addition, a report published in Germany indicates that SAMe may help maintain healthy neurological function. The report revealed that:

• SAMe increased glutathionelevels by 50% and glutathione enzyme activity by 115%.
• SAMe decreased a measurement of free radical activity by 46%.
• SAMe inhibited lipid peroxidation by 55% in culture.

SAMe's ability to boost brain cell methylation facilitates youthful DNA enzymatic actions which may help account for SAMe’s mood-elevating properties. These enzymatic reactions are required for the healthy conversion of neurotransmitters such as serotonin and dopamine.

Caution: SAMe should not be taken by those diagnosed with bipolar disorder.